The ubiquitous nature of the IGF system, expressed early in embryonic development
throughout postnatal and adult life, indicates a key role for this system in human biology …

The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and
transduced by various intracellular signal pathways is modulated by the IGF Binding …

One of the hallmarks in the advancement of cancer cells is an ability to overcome and
acquire resistance to adverse conditions. There has been a large amount of cancer research …

Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has traditionally been defined by its
role as a binding protein and its association with IGF delivery and availability. Development …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

IGFBP-6 is an O-linked glycoprotein that preferentially binds IGF-II over IGF-I. It is a relatively
selective inhibitor of IGF-II actions including proliferation, survival and differentiation of a …

Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as
an IGF system regulator, controlling the distribution, function, and activity of IGFs in the …

Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that
has both extracellular and intracellular functions. Despite a clear causal role in cancer …

IGF activity is regulated tightly by a family of IGF binding proteins (IGFBPs). IGFBP‐5 is the
most conserved of these and is up‐regulated significantly during differentiation of several …