Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
M Kulis, S Heath, M Bibikova, AC Queirós, A Navarro… - Nature …, 2012 - nature.com
We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia
L Pei, JH Choi, J Liu, EJ Lee, B McCarthy, JM Wilson… - Epigenetics, 2012 - Taylor & Francis
We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from chronic
lymphocytic leukemia (CLL) patients and normal control samples using reduced …
lymphocytic leukemia (CLL) patients and normal control samples using reduced …
Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact
WG Tong, WG Wierda, E Lin, SQ Kuang, BN Bekele… - Epigenetics, 2010 - Taylor & Francis
We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic
leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter …
leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter …
Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia
Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary
course of cancer. Chronic lymphocytic leukaemia (CLL) is a highly informative model for …
course of cancer. Chronic lymphocytic leukaemia (CLL) is a highly informative model for …
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
Charting differences between tumors and normal tissue is a mainstay of cancer research.
However, clonal tumor expansion from complex normal tissue architectures potentially …
However, clonal tumor expansion from complex normal tissue architectures potentially …
Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia
Although clonal selection by genetic driver aberrations in cancer is well documented, the
ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k …
ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k …
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia
L Yu, C Liu, J Vandeusen, B Becknell, Z Dai, YZ Wu… - Nature …, 2005 - nature.com
DNA methylation is associated with malignant transformation, but limitations imposed by
genetic variability, tumor heterogeneity, availability of paired normal tissues and …
genetic variability, tumor heterogeneity, availability of paired normal tissues and …
[HTML][HTML] Acute lymphoblastic leukemia displays a distinct highly methylated genome
DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …
450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative …
N Cahill, AC Bergh, M Kanduri, H Göransson-Kultima… - Leukemia, 2013 - nature.com
In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression
patterns; however, knowledge is limited regarding the extent to which methylation changes …
patterns; however, knowledge is limited regarding the extent to which methylation changes …
Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease
AE Rodriguez-Vicente, MG Díaz, JM Hernández-Rivas - Cancer genetics, 2013 - Elsevier
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL), with
survival times ranging from months to decades, reflects its biological diversity. Our …
survival times ranging from months to decades, reflects its biological diversity. Our …