METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

X Yang, S Zhang, C He, P Xue, L Zhang, Z He, L Zang… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic
regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is …

Retracted: Mettl14 suppresses crc progression Via regulating N6-Methyladenosine-Dependent primary mir-375 processing

X Chen, M Xu, X Xu, K Zeng, X Liu, L Sun, B Pan, B He… - Molecular Therapy, 2020 - cell.com
Epigenetic alterations contributed to human carcinogenesis immensely. N6-
methyladenosine (m6A) is one of the most preventive and abundant modifications on RNA …

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

T Li, PS Hu, Z Zuo, JF Lin, X Li, QN Wu, ZH Chen… - Molecular cancer, 2019 - Springer
Background Colorectal carcinoma (CRC) is one of the most common malignant tumors, and
its main cause of death is tumor metastasis. RNA N 6-methyladenosine (m 6 A) is an …

[HTML][HTML] RNA N6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m6A-GLUT1-mTORC1 axis and is a therapeutic target

H Chen, S Gao, W Liu, CC Wong, J Wu, J Wu, D Liu… - Gastroenterology, 2021 - Elsevier
Background & Aims RNA N 6-methyladenosine (m 6 A) modification has recently emerged
as a new regulatory mechanism in cancer progression. We aimed to explore the role of the …

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

R Deng, Y Cheng, S Ye, J Zhang, R Huang… - OncoTargets and …, 2019 - Taylor & Francis
Purpose Although many biological processes are involved in the modification of N6-
methyladenosine (m6A), the exact role of m6A in the development of malignant tumors …

[HTML][HTML] N6-methyladenosine methyltransferase METTL3 promotes colorectal cancer cell proliferation through enhancing MYC expression

S Xiang, X Liang, S Yin, J Liu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) modification is the most common chemical modification
in eukaryotic mRNA, which plays a crucial role in regulating mRNA stability, splicing, and …

METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

J Pan, F Liu, X Xiao, R Xu, L Dai, M Zhu, H Xu… - Journal of Experimental …, 2022 - Springer
Background Colorectal carcinoma (CRC) is the third most common cancer and second most
common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6 …

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

X Chen, MU Xu, X Xu, K Zeng, X Liu, B Pan, C Li… - Molecular cancer, 2020 - Springer
Background Colorectal cancer (CRC) is one of the leading causes of tumor-related death
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …

[HTML][HTML] Expression patterns and prognostic value of m6A-related genes in colorectal cancer

X Liu, L Liu, Z Dong, J Li, Y Yu, X Chen… - American journal of …, 2019 - ncbi.nlm.nih.gov
Colorectal cancer (CRC), including colon adenocarcinoma (COAD) and rectal
adenocarcinoma (READ), is one of the most prevalent malignancies worldwide. N 6 …

[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

H Chen, Y Pan, Q Zhou, C Liang, CC Wong, Y Zhou… - Gastroenterology, 2022 - Elsevier
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …