Pharmacokinetics during therapeutic hypothermia in neonates: from pathophysiology to translational knowledge and physiologically-based pharmacokinetic (PBPK) …
K Leys, MS Stroe, P Annaert… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …
A physiology-based pharmacokinetic framework to support drug development and dose precision during therapeutic hypothermia in neonates
A Smits, P Annaert, S Van Cruchten… - Frontiers in …, 2020 - frontiersin.org
Therapeutic hypothermia (TH) is standard treatment for neonates (≥ 36 weeks) with
perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and …
perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and …
The impact of hypothermia on the pharmacokinetics of drugs used in neonates and young infants
P Pokorna, ED Wildschut, V Vobruba… - Current …, 2015 - ingentaconnect.com
Therapeutic hypothermia (HT) is frequently used in neonates with hypoxic-ischemic
encephalopathy and young infants during cardiopulmonary bypass (CPB). Hypothermia and …
encephalopathy and young infants during cardiopulmonary bypass (CPB). Hypothermia and …
[HTML][HTML] Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps
MS Stroe, L Van Bockstal, A Valenzuela… - Frontiers in …, 2023 - frontiersin.org
Animal models provide useful information on mechanisms in human disease conditions, but
also on exploring (patho) physiological factors affecting pharmacokinetics, safety, and …
also on exploring (patho) physiological factors affecting pharmacokinetics, safety, and …
Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study
TR de Haan, YA Bijleveld, JH van der Lee… - BMC pediatrics, 2012 - Springer
Abstract Background In the Netherlands, perinatal asphyxia (severe perinatal oxygen
shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 …
shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 …
[HTML][HTML] Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review
IC Lutz, K Allegaert, JN de Hoon… - BMJ Paediatrics …, 2020 - ncbi.nlm.nih.gov
Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …
Physiologic and pharmacologic considerations for hypothermia therapy in neonates
S Zanelli, M Buck, K Fairchild - Journal of Perinatology, 2011 - nature.com
With mounting evidence that hypothermia is neuroprotective in newborns with hypoxic-
ischemic encephalopathy (HIE), an increasing number of centers are offering this therapy …
ischemic encephalopathy (HIE), an increasing number of centers are offering this therapy …
Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of …
LMA Favié, TR de Haan, YA Bijleveld… - Clinical …, 2020 - Wiley Online Library
Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is
challenging; exposure is dependent on body size and maturation but can also be influenced …
challenging; exposure is dependent on body size and maturation but can also be influenced …
Physiological responses to hypothermia
T Wood, M Thoresen - Seminars in fetal and neonatal medicine, 2015 - Elsevier
Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …
Physiologic and pharmacologic effects of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy
S Zanelli, K Fairchild - Newborn and Infant Nursing Reviews, 2009 - Elsevier
Therapeutic hypothermia is emerging as a promising intervention to improve the
neurodevelopmental outcome of infants with moderate to severe hypoxic-ischemic …
neurodevelopmental outcome of infants with moderate to severe hypoxic-ischemic …