Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …

Therapeutic hypothermia (TH) is standard treatment for neonates (≥ 36 weeks) with
perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and …

Therapeutic hypothermia (HT) is frequently used in neonates with hypoxic-ischemic
encephalopathy and young infants during cardiopulmonary bypass (CPB). Hypothermia and …

Animal models provide useful information on mechanisms in human disease conditions, but
also on exploring (patho) physiological factors affecting pharmacokinetics, safety, and …

Abstract Background In the Netherlands, perinatal asphyxia (severe perinatal oxygen
shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 …

Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …

With mounting evidence that hypothermia is neuroprotective in newborns with hypoxic-
ischemic encephalopathy (HIE), an increasing number of centers are offering this therapy …

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is
challenging; exposure is dependent on body size and maturation but can also be influenced …

Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …

Therapeutic hypothermia is emerging as a promising intervention to improve the
neurodevelopmental outcome of infants with moderate to severe hypoxic-ischemic …