The somatic genomic landscape of glioblastoma
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
Summary The Cancer Genome Atlas Network recently cataloged recurrent genomic
abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression …
abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression …
[HTML][HTML] An integrative model of cellular states, plasticity, and genetics for glioblastoma
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable
and poorly understood tumor, but their precise characterization remains challenging. Here …
and poorly understood tumor, but their precise characterization remains challenging. Here …
Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date
JIL Bastien, KA McNeill, HA Fine - Cancer, 2015 - Wiley Online Library
During the last decade, extensive multiplatform genome‐wide analysis has yielded a wealth
of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme …
of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme …
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
C Brennan, H Momota, D Hambardzumyan, T Ozawa… - PloS one, 2009 - journals.plos.org
Background Glioblastoma multiforme (GBM) is an umbrella designation that includes a
heterogeneous group of primary brain tumors. Several classification strategies of GBM have …
heterogeneous group of primary brain tumors. Several classification strategies of GBM have …
Molecular classification of gliomas
The identification of distinct genetic and epigenetic profiles in different types of gliomas has
revealed novel diagnostic, prognostic, and predictive molecular biomarkers for refinement of …
revealed novel diagnostic, prognostic, and predictive molecular biomarkers for refinement of …
Advances in the molecular genetics of gliomas—implications for classification and therapy
G Reifenberger, HG Wirsching… - Nature reviews Clinical …, 2017 - nature.com
Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …
alterations and epigenetic profiles associated with different types of gliomas. These …
Epigenetic mechanisms in glioblastoma multiforme
RP Nagarajan, JF Costello - Seminars in cancer biology, 2009 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive and lethal cancer, accounting for the
majority of primary brain tumors in adults. GBMs are characterized by genetic alterations …
majority of primary brain tumors in adults. GBMs are characterized by genetic alterations …
[HTML][HTML] Molecular and genomic alterations in glioblastoma multiforme
I Crespo, AL Vital, M Gonzalez-Tablas… - The American journal of …, 2015 - Elsevier
In recent years, important advances have been achieved in the understanding of the
molecular biology of glioblastoma multiforme (GBM); thus, complex genetic alterations and …
molecular biology of glioblastoma multiforme (GBM); thus, complex genetic alterations and …
Integration and analysis of genome-scale data from gliomas
G Riddick, HA Fine - Nature Reviews Neurology, 2011 - nature.com
Primary brain tumors are a leading cause of cancer-related mortality among young adults
and children. The most common primary malignant brain tumor, glioma, carries a median …
and children. The most common primary malignant brain tumor, glioma, carries a median …