Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

Methionine is the initiator amino acid for protein synthesis, the methyl source for most
nucleotide, chromatin, and protein methylation, and the carbon backbone for various …

The essential amino acid, methionine, is important for cancer cell growth and metabolism. A
growing body of evidence indicates that methionine restriction inhibits cancer cell growth …

Conventional chemotherapies have showed their limits, notably for patients with advanced
cancer. New therapeutic strategies must be identified, and the metabolic abnormalities of …

Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from
oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is …

Availability of the amino acid methionine shows remarkable effects on the physiology of
individual cells and whole organisms. For example, most cancer cells, but not normal cells …

Methionine is an essential amino acid with many key roles in mammalian metabolism such
as protein synthesis, methylation of DNA and polyamine synthesis. Restriction of methionine …

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

Nutrition exerts considerable effects on health, and dietary interventions are commonly used
to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic …

Normal cells can synthesize sufficient methionine for growth requirements from
homocysteine and 5-methyltetrahydrofolate and vitamin B12. However, many cancer-cell …