Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders

J Zhou, Q Chen, PR Braun… - Proceedings of the …, 2022 - National Acad Sciences
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …

[HTML][HTML] Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

AE Jaffe, Y Gao, A Deep-Soboslay, R Tao… - Nature …, 2016 - nature.com
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

[HTML][HTML] Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA …

BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …

[HTML][HTML] Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia

R Pidsley, J Viana, E Hannon, H Spiers, C Troakes… - Genome biology, 2014 - Springer
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …

[HTML][HTML] Cell type-specific epigenetic links to schizophrenia risk in the brain

I Mendizabal, S Berto, N Usui, K Toriumi, P Chatterjee… - Genome biology, 2019 - Springer
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …

[HTML][HTML] A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score

DM Ciuculete, AE Boström, S Voisin, H Philipps… - Translational …, 2017 - nature.com
Genome-wide association studies have identified a number of single-nucleotide
polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of …

[HTML][HTML] Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation

SJ Goodman, CL Burton, DT Butcher, MT Siu… - Journal of …, 2020 - Springer
Background A growing body of research has demonstrated associations between specific
neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this …

[HTML][HTML] An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation

E Hannon, E Dempster, J Viana, J Burrage, AR Smith… - Genome biology, 2016 - Springer
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …

[HTML][HTML] Alteration of DNA methylation and epigenetic scores associated with features of schizophrenia and common variant genetic risk

DJ Kiltschewskij, WR Reay, MP Geaghan, JR Atkins… - Biological …, 2024 - Elsevier
Background Unpacking molecular perturbations associated with features of schizophrenia is
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …