Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
[HTML][HTML] Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
[HTML][HTML] Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA …
BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
[HTML][HTML] Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …
result from disturbances in early brain development. There is mounting evidence to support …
[HTML][HTML] Cell type-specific epigenetic links to schizophrenia risk in the brain
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
[HTML][HTML] A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score
DM Ciuculete, AE Boström, S Voisin, H Philipps… - Translational …, 2017 - nature.com
Genome-wide association studies have identified a number of single-nucleotide
polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of …
polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of …
[HTML][HTML] Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation
SJ Goodman, CL Burton, DT Butcher, MT Siu… - Journal of …, 2020 - Springer
Background A growing body of research has demonstrated associations between specific
neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this …
neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this …
[HTML][HTML] An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
[HTML][HTML] Alteration of DNA methylation and epigenetic scores associated with features of schizophrenia and common variant genetic risk
Background Unpacking molecular perturbations associated with features of schizophrenia is
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …
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