Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Cryptococcal infections burden the immunocompromised population with unacceptably high
morbidity and mortality. This population includes HIV-infected individuals and those …

Half a century after the introduction of Amphotericin B the management of cryptococcosis
remains unsatisfactory. The disease, caused primarily by the two fungal species …

The significance of cryptococcal infection as a cause of human disease has dramatically
evolved in recent years. The objective of this study was to outline the worldwide significance …

Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Cryptococcus spp. conveys a high disease burden among immunocompromised hosts.
Clinicians must consider numerous variables and factors in a dynamic way to offer the best …

Increasing resistance to frontline antifungals is a growing threat to global health. In the face
of high rates of relapse for patients with cryptococcal meningitis and frequent drug …

New, more accessible therapies for cryptococcosis represent an unmet clinical need of
global importance. We took a repurposing approach to identify previously developed drugs …

Cryptococcosis is an infection of global significance, affecting both immunocompromised
and immunocompetent hosts. Traditionally, 2 main species of yeasts caused cryptococcosis …