Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

Complement is a major defense system of innate immunity and aimed to destroy microbes.
One of the central complement regulators is factor H, which belongs to a protein family that …

Factor H (FH) is a key alternative pathway regulator that controls complement activation both
in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …

The role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen
defense, and autoimmune disease has recently attracted considerable interest. We highlight …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

Complement is an essential part of innate immunity as it participates in host defense against
infections, disposal of cellular debris and apoptotic cells, inflammatory processes and …