Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic
recruitment and expansion of multiple cell types that interact in multifaceted ways within a …

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

Mesenchymal stromal cells have emerged as powerful modulators of the immune system. In
this study, we explored how the human macrophage response to TNF is regulated by human …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic …

Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLSs) and synovial
macrophages (SMs), are crucial for the progression of rheumatoid arthritis (RA). Particularly …

Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that
remains an unmet medical need despite improved therapy. This limitation likely reflects the …

Rheumatoid arthritis (RA) is a prototypical autoimmune disease that causes destructive
tissue inflammation in joints and elsewhere. Clinical challenges in RA include the empirical …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …