The use of assisted reproductive technology (ART) to overcome fertility problems has
continued to increase since the birth of the first baby conceived by ART over 30 years ago …

The first crucial step in the developmental program occurs during pre-implantation, the time
after the oocyte has been fertilized and before the embryo implants in the uterus. This period …

Current scientific literature increasingly documents a correlation between assisted
reproductive technologies (ART) and epigenetic errors in the children born, attributed to …

Although assisted reproductive technologies (ARTs) have allowed millions of otherwise
infertile couples to conceive children of their own, concerns remain about the safety of these …

The early stage of mammalian development from fertilization to implantation is a period
when global and differential changes in the epigenetic landscape occur in paternally and …

DNA methylation is an important epigenetic modification that undergoes dynamic changes
in mammalian embryogenesis, during which both parental genomes are reprogrammed …

Abstract Knowledge about preimplantation development is important both for basic
reproductive biology and for practical applications, including livestock breeding and …

During early mammalian embryogenesis, there is a wave of DNA demethylation
postfertilization and de novo methylation around implantation. The paternal genome …

Imprinted genes, which are epigenetically modified such that only a single parental allele is
expressed, are often regulated by imprinting control regions (ICRs). ICRs typically are DNA …

Background Assisted reproductive technologies (ART) are widely used to treat fertility issues
in humans and for the production of embryos in mammalian livestock. The use of these …