The cell biology of polycystic kidney disease
Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …
Kidney: polycystic kidney disease
BM Paul, GB Vanden Heuvel - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the
presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal …
presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal …
[HTML][HTML] New insights into the molecular pathophysiology of polycystic kidney disease
NS Murcia, WE Sweeney Jr, ED Avner - Kidney international, 1999 - Elsevier
New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …
Somatic mutations in renal cyst epithelium in autosomal dominant polycystic kidney disease
AY Tan, T Zhang, A Michaeel… - Journal of the …, 2018 - journals.lww.com
Background Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy caused
by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell …
by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell …
Overexpression of PKD1 causes polycystic kidney disease
C Thivierge, A Kurbegovic, M Couillard… - … and cellular biology, 2006 - Am Soc Microbiol
The pathogenetic mechanisms underlying autosomal dominant polycystic kidney disease
(ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency …
(ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency …
Pkd1 inactivation induced in adulthood produces focal cystic disease
A Takakura, L Contrino, AW Beck… - Journal of the American …, 2008 - journals.lww.com
Autosomal dominant polycystic kidney disease, the most common monogenetic disorder, is
characterized by gradual replacement of normal renal parenchyma by fluid-filled cysts …
characterized by gradual replacement of normal renal parenchyma by fluid-filled cysts …
Molecular advances in autosomal dominant polycystic kidney disease
AR Gallagher, GG Germino, S Somlo - Advances in chronic kidney disease, 2010 - Elsevier
Autosomal dominant polycystic disease (ADPKD) is the most common form of inherited
kidney disease that results in renal failure. The understanding of the pathogenesis of …
kidney disease that results in renal failure. The understanding of the pathogenesis of …
[HTML][HTML] Polycystic kidney disease: pathogenesis and potential therapies
V Takiar, MJ Caplan - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2011 - Elsevier
Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition
for which there is currently no effective specific clinical therapy. The disease is characterized …
for which there is currently no effective specific clinical therapy. The disease is characterized …
Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and potential therapies
T Mochizuki, K Tsuchiya, K Nitta - Clinical and experimental nephrology, 2013 - Springer
Autosomal dominant polycystic kidney disease (ADPKD) is the most common progressive
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …