Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T
cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation …

ZAP-70 tyrosine kinase is involved in signalling pathways following T-cell receptor
stimulation and was originally described only in T cells and natural killer cells. ZAP-70 …

The role of ZAP-70 expression on the ex vivo response of blood cells from CLL and PLL
patients to a combination of fludarabine, a purine analog, and genistein, a tyrosine kinase …

The expression of ZAP-70 in a subset of chronic lymphocytic leukemia (CLL) patients
strongly correlates with a more aggressive clinical course, although the exact underlying …

Gene expression profiling reveals differences in microenvironment interaction between patients
with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA - PMC Back to …

Expression of ZAP-70 is an important negative prognostic factor in chronic lymphocytic
leukemia (CLL). This protein tyrosine kinase is a key mediator of T-cell receptor (TCR) …

Background Recent studies have reported that zeta-chain-associated protein kinase 70
(ZAP-70) expression plays a prognostic role in chronic lymphocytic leukemia (CLL) …

Chronic lymphocytic leukaemia (CLL) is a disease with a highly variable prognosis. The
clinical course can however be predicted thanks to prognostic markers. Poor prognosis is …

Zeta‐associated protein of 70 kD (ZAP 70) is a recognized adverse prognostic marker in
chronic lymphocytic leukaemia (CLL) associated with enhanced B‐cell receptor signalling …

ZAP-70 in chronic lymphocytic leukemia (CLL) has been associated with enhanced B-cell
receptor (BCR) signaling, survival, and migration. We investigated whether ZAP-70 can …