Purpose: The aim of this study was to investigate the promoter hypermethylation as
diagnostic markers to detect malignant prostate cells and as prognostic markers to predict …

Altered genome methylation is a hallmark of human malignancies. In this study, high-
throughput analyses of concordant gene methylation and expression events were performed …

Background: One challenge in prostate cancer is distinguishing indolent from aggressive
disease at diagnosis. DNA promoter hypermethylation is a frequent epigenetic event in …

Background We identify and validate accurate diagnostic biomarkers for prostate cancer
through a systematic evaluation of DNA methylation alterations. Materials and methods We …

BACKGROUND DNA hypermethylation has emerged as a novel molecular biomarker for the
evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene …

Purpose We conducted a systematic review to summarize current evidence on the
prognostic utility of DNA methylation markers in prostate cancer and ascertain knowledge …

Purpose: Aberrant gene promoter methylation profiles have been well-studied in human
prostate cancer. Therefore, we rationalize that multigene methylation analysis could be …

The molecular diversity of prostate cancer (PCa) has been demonstrated by recent genome-
wide studies, proposing a significant number of different molecular markers. However, only a …

Promoter DNA methylation of CpG islands is an important epigenetic mechanism in cancer
development. We have characterized the promoter methylation profile of 82 genes in three …

Purpose: We investigated the aberrant methylation profile of prostate cancers and correlated
the data with clinical findings. Experimental Design: Gene promoter methylation was …