DNA methylation patterns and epigenetic memory
A Bird - Genes & development, 2002 - genesdev.cshlp.org
The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
Notes on the role of dynamic DNA methylation in mammalian development
TH Bestor, JR Edwards… - Proceedings of the …, 2015 - National Acad Sciences
It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …
transmitted via maintenance methylation during S phase and might play a role in the …
DNA methylation and embryogenesis
A Razin, H Cedar - DNA methylation: molecular biology and biological …, 1993 - Springer
A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …
and repeated sequences in different tissues of various mammalian species. This has …
DNA methylation and epigenetic mechanisms
R Holliday - Cell biophysics, 1989 - Springer
Genes are essential for the transmission of genetic information from generation to
generation, and this mechanism of inheritance is fully understood. Genes are also essential …
generation, and this mechanism of inheritance is fully understood. Genes are also essential …
Maintenance and regulation of DNA methylation patterns in mammals
Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …
correct development of complex organisms. For mammals, it is now accepted that DNA …
DNA methylation in early development
A Razin, R Shemer - Human Molecular Genetics, 1995 - academic.oup.com
Several lines of evidence strongly suggest that DNA methylation is involved in embryo
development. Perhaps the most direct evidence comes from experiments with …
development. Perhaps the most direct evidence comes from experiments with …
Inheritance of allelic blueprints for methylation patterns
AJ Silva, R White - Cell, 1988 - cell.com
We have developed a strategy to distinguish between the methylation patterns of
homologous chromosomes in tissues, and to follow these patterns in human pedigrees. This …
homologous chromosomes in tissues, and to follow these patterns in human pedigrees. This …
Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues
Mammalian development requires cytosine methylation, a heritable epigenetic mark of
cellular memory believed to maintain a cell's unique gene expression pattern. However, it …
cellular memory believed to maintain a cell's unique gene expression pattern. However, it …
Methylation and epigenetic fidelity
AD Riggs, Z Xiong - … of the National Academy of Sciences, 2004 - National Acad Sciences
Mammalian cellular differen-tiation and development depend on stable, somatically
heritable epigenetic switches. A good example is X chromosome inactivation, the random …
heritable epigenetic switches. A good example is X chromosome inactivation, the random …
Dynamics of DNA methylation during development
M Brandeis, M Ariel, H Cedar - Bioessays, 1993 - Wiley Online Library
DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …