The rapid increase of omic data has greatly facilitated the investigation of associations
between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts …

Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

ABSTRACT DNA methylation is an important epigenetic mechanism that has been linked to
complex diseases and is of great interest to researchers as a potential link between …

Characterizing the complex relationship between genetic, epigenetic, and transcriptomic
variation has the potential to increase understanding about the mechanisms underpinning …

Epigenome-wide association studies (EWAS) seek to quantify associations between
traits/exposures and DNA methylation measured at thousands or millions of CpG sites …

Polygenic approaches often access more variance of complex traits than is possible by
single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for …

Motivation: A common difficulty in large-scale microarray studies is the presence of
confounding factors, which may significantly skew estimates of statistical significance, cause …

Motivation High-dimensional DNA methylation (DNAm) array coverage, while sparse in the
context of the entire DNA methylome, still constitutes a very large number of CpG probes …

Recent technological advances in molecular biology have given rise to numerous large‐
scale datasets whose analysis imposes serious methodological challenges mainly relating …

Most genetic variants identified in genome-wide association studies (GWASs) of complex
traits are thought to act by affecting gene regulation rather than directly altering the protein …