Background Factor H-related protein 5 (FHR-5) is a member of the complement Factor H
protein family. Due to the homology to Factor H, the main complement regulator of the …

C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative
glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of …

Introduction Therapeutic agents that target complement are increasingly available for
glomerular diseases. However, the mechanisms linking glomerular complement deposition …

Human complement Factor H-related protein 1 (FHR-1) is one of complement Factor H-
related proteins (FHRs) and plays an important role in innate immunity. In particular, FHR-1 …

C3 glomerulopathies (C3G) are a group of severe renal diseases with distinct patterns of
glomerular inflammation and C3 deposition caused by complement dysregulation. Here we …

Background C3 glomerulopathy (C3G) is a heterogeneous group of chronic renal diseases
characterized predominantly by glomerular C3 deposition and complement dysregulation …

Genetic variation within the factor H–related (FHR) genes is associated with the complement-
mediated kidney disease, C3 glomerulopathy (C3G). There is no definitive treatment for …

Introduction Immunoglobulin A nephrology (IgAN), characterized by co-deposition of IgA and
complement components, is an activation of complement system involved disease. Factor H …

The physiological roles of the factor H (FH)-related proteins are controversial and poorly
understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in …

Abstract C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease
characterized histologically by the predominance of C3 deposition within in the glomerulus …