The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

In the mammalian somatosensory system, mechanosensitive neurons mediate the senses of
touch and pain. Among sensory modalities, mechanosensation has been the most elusive …

Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical
signals. The proteins that transduce these signals and underlie these senses, however, are …

▪ Abstract Mechanosensation, the transduction of mechanical forces into a cellular
electrochemical signal, enables living organisms to detect touch; vibrations, such as sound; …

How desensitization of mechanotransducer currents regulates afferent signal generation in
mammalian sensory neurons is essentially unknown. Here, we dissected desensitization …

The ability of cells to detect and transduce mechanical stimuli impinging on them is a
fundamental process that underlies normal cell growth, hearing, balance, touch, and pain …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

The gating of ion channels by mechanical force underlies the sense of touch and pain. The
mode of gating of mechanosensitive ion channels in vertebrate touch receptors is unknown …

▪ Abstract Mechanosensation has been studied for decades, but understanding of its
molecular mechanism is only now emerging from studies in Caenorhabditis elegans and …

Mechanosensory transduction underlies a wide range of senses, including proprioception,
touch, balance, and hearing. The pivotal element of these senses is a mechanically gated …