Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation
of programmed cell death (apoptosis) during normal development as well as in adult life …

Caspase-8 is an apical caspase which initiates programmed cell death following death
receptor ligation. This central role in apoptosis has prompted significant clinical interest in …

Introduction: Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial
apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is …

As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …

Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter
of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells. With the …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Caspase-2 belongs to the caspase family of proteins responsible for essential cellular
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …

Caspase-7 was considered to be redundant with caspase-3 because these related cysteine
proteases share an optimal peptide recognition sequence and have several endogenous …

Caspase-8 was originally identified as a central player of programmed cell death triggered
by death receptor stimulation. In that context, its activity is tightly regulated through several …