DNA methylation marks, a key modification of imprinting, are erased in primordial germ cells
and sex specifically re-established during gametogenesis. Abnormal epigenetic …

OBJECTIVE: To study the methylation imprinting marks of two oppositely imprinted genes,
H19 and MEST/PEG1, in human testicular spermatozoa from azoospermic patients with …

Genomic imprinting marks in the male germ line are already established in the adult
germinal stem cell population. We studied the methylation patterns of H19 and MEST …

Imprinted genes are expressed either from the paternal or the maternal allele, because the
other allele has been silenced in the mother's or father's germline. Imprints are characterized …

Paternal imprinting marks were shown to be erased in the mouse primordial germ cells and
progressively re-established throughout the male germ line development, starting in fetal …

Background Male infertility is a complex disease caused by a combination of genetic,
environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed …

Aberrant imprinting in spermatozoa in a subset of infertile men has been postulated to be a
risk factor for congenital diseases in children conceived via assisted reproduction …

Male factor infertility has been associated with abnormal DNA methylation at imprinted
genes. Little information is available on the status of imprinting in the sperm of men with …

OBJECTIVE: To evaluate the associations between proper protamine incorporation and
DNA methylation at imprinted loci. DESIGN: Experimental research study. SETTING …

STUDY QUESTION What is the sperm DNA methylation status of imprinted genes in male
partners from couples experiencing recurrent pregnancy loss (RPL)? SUMMARY ANSWER …