Autophagy is an evolutionarily conserved stress response mechanism that often occurs in
apoptosis-defective cancer cells and can protect against cell death. In this study, we …

Autophagy is often found in apoptosis-defective cancer cells and contributes to
chemotherapy resistance. However, it is far from clear how the coordination of apoptosis and …

Beclin 1, identified as a Bcl-2-interacting protein, is known to enhance autophagy. However,
the effect of Beclin 1 on apoptotic signaling has remained unclear. Here, we show that …

Beclin 1 acts as a tumor suppressor and is an essential mediator of autophagy. Beclin 1 also
interacts with Bcl-2 and can induce apoptosis by activating the mitochondrion …

Cancer cells have developed novel mechanisms for evading chemotherapy-induced
apoptosis and autophagy-associated cell death pathways. Upon the discovery that …

Autophagy and apoptosis are both highly regulated biological processes that play essential
roles in tissue homeostasis, development and diseases. Autophagy is also described as a …

Autophagy and apoptosis are two important and interconnected stress-response
mechanisms. However, the molecular interplay between these two pathways is not fully …

Background Beclin1 is a well-known key regulator of autophagy, which is also a
haploinsufficient tumor suppressor. Current studies revealed that down-regulation or …

To investigate the role of Beclin1 in cisplatin-induced apoptosis in laryngeal carcinoma cells
Hep-2 and to explore the potential mechanism. We up-regulated Beclin1 expression in Hep …

Abstract Beclin-1, a well-known key regulator of autophagy, has been implicated in many
disorders, including cancer, aging, and degenerative diseases. Previous studies …