DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo
Somatic mutations in DNMT3A are recurrent events across a range of blood cancers.
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …
DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
Despite the clinical impact of DNMT3A mutation on acute myeloid leukaemia, the molecular
mechanisms regarding how this mutation causes leukaemogenesis in vivo are largely …
mechanisms regarding how this mutation causes leukaemogenesis in vivo are largely …
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
A Mayle, L Yang, B Rodriguez, T Zhou… - Blood, The Journal …, 2015 - ashpublications.org
Abstract DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
Dnmt3a silences hematopoietic stem cell self-renewal
JJ Trowbridge, SH Orkin - Nature genetics, 2012 - nature.com
DNA methylation is an epigenetic mark stably directing gene expression throughout
development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in …
development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in …
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells
Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response
M Scheller, AK Ludwig, S Göllner, C Rohde, S Krämer… - Nature Cancer, 2021 - nature.com
Somatic mutations in DNA methyltransferase 3A (DNMT3A) are among the most frequent
alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot …
alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot …
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
JJ Trowbridge, AU Sinha, N Zhu, M Li… - Genes & …, 2012 - genesdev.cshlp.org
Epigenetic mechanisms regulating leukemia stem cells (LSCs) are an attractive target for
therapy of blood cancers. Here, we report that conditional knockout of the DNA …
therapy of blood cancers. Here, we report that conditional knockout of the DNA …