Background During mammalian early embryogenesis, expression and epigenetic
heterogeneity emerge before the first cell fate determination, but the programs causing such …

The generation of genome-wide data derived from methylated DNA immunoprecipitation
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …

Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes.
Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA …

During mammalian embryo development, reprogramming of DNA methylation plays
important roles in the erasure of parental epigenetic memory and the establishment of naive …

The precise and timely expression of genes, starting as soon as initial fertilization and
continuously throughout fetal tissue progression, is crucial to ensure the proper …

In mammals, all somatic development originates from lineage segregation in early embryos.
However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell …

Human preimplantation development is characterized by low developmental rates that are
poorly understood. Early mammalian embryogenesis is characterized by a major phase of …

The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …