Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of
epithelial cells and the influx of cyst fluid. The 14-kb mRNA of the polycystic kidney disease …

Abstract Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is
characterized by the formation of multiple fluid-filled cysts that destroy the kidney …

The major form of autosomal dominant polycystic kidney disease (ADPKD) results from
mutation of a gene (PKD1) of unknown function that is essential for the later stages of renal …

We previously reported that the tumor suppressor protein p53 participates in a negative
feedback loop to fine-tune PKD1 gene expression. This physiological pathway is believed to …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common human
monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the …

Background The major form of autosomal dominant polycystic kidney disease is caused by
heterozygous mutations in PKD1, the gene that encodes polycystin-1 (PC1). Unlike PKD1 …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
multiple fluid-filled cysts that expand over time and destroy the renal architecture. Loss or …

Although much is known about the molecular genetic mechanisms of autosomal-dominant
polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we …

Mutations of either PKD1 or PKD2 are associated with autosomal dominant polycystic
kidney disease (ADPKD). The molecular function of the gene product of PKD1, polycystin-1 …

Autosomal-dominant polycystic kidney disease results from at least two causal genes, PKD1
and PKD2. The identical clinical phenotype in human patients and targeted Pkd1 and Pkd2 …