Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a slowly progressive
disease characterized by the relentless growth of renal cysts throughout the life of affected …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Recent studies have reported intrinsic metabolic reprogramming in Pkd1 knock-out cells,
implicating dysregulated cellular metabolism in the pathogenesis of polycystic kidney …

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder,
characterized by bilateral renal cyst formation. Multiple pathways are de‐regulated in cystic …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder
caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent …

Autosomal dominant polycystic kidney disease is characterized by progressive development
and enlargement of kidney cysts, leading to ESKD. Because the kidneys are under high …

Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …

Since polycystic kidney disease (PKD) was first noted over 30 years ago to have neoplastic
parallels, there has been a resurgent interest in elucidating neoplasia-relevant pathways in …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
kidney disease and affects 1 in 1,000 individuals. There is accumulating evidence …

Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship
due to tethering proteins that bring their membranes in close (~ 30 nm) apposition. One …