Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other
organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically …

Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

Abstract Three-dimensional, organ-on-chip models that recapitulate kidney tissue are
needed for drug screening and disease modeling. Here, we report a method for creating a …

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end
stage renal disease characterized by progressive expansion of kidney cysts. To better …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts …

Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating
human kidney are the attractive tool for kidney regeneration, disease modeling, and drug …

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by
mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is …

Pluripotent stem cell‐derived kidney organoids offer a promising solution to renal failure, yet
current organoid protocols often lead to off‐target cells and phenotypic alterations …

Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …