Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional
and/or genetic disruptions in homocysteine metabolism. The most common genetic cause of …

Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to
hyperhomocysteinemia and vascular disease. We tested the hypothesis that heterozygous …

Genetic disorders of homocysteine (Hcy) metabolism or a high‐methionine diet lead to
elevations of plasma Hcy levels. In humans, severe genetic hyperhomocysteinemia results …

M ethylenetetrahydrofolate and clarified homocysteine our understanding metabolism.
reductase of MTHFR Research (MTHFR) deficiencies performed is a that key cause during …

Abstract The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the
folate metabolism pathway, the byproducts of which are involved in the remethylation of …

Background—The results of retrospective and prospective case-control studies have clearly
established that mild elevations of the plasma homocysteine level are associated with …

Background Increased homocysteine levels are a risk factor for atherosclerosis and its
sequelae. A common genetic mutation in methylenetetrahydrofolate reductase (MTHFR), an …

Molecular defects in genes encoding enzymes involved in homocysteine metabolism may
account for mild hyperhomocysteinemia, an independent and graded risk factor for …

Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine,
an essential amino acid, and is metabolized by one of two pathways: remethylation or …

Mild hyperhomocysteinaemia is a major risk factor for vascular disease and neural tube
defects (NTDs), conferring an approximately three-fold relative risk for each condition. It has …