Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type
Background Individual genotypes at specific loci can result in different patterns of DNA
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
Background Genetic influence on DNA methylation is potentially an important mechanism
affecting individual differences in humans. We use next-generation sequencing to assay …
affecting individual differences in humans. We use next-generation sequencing to assay …
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
A fundamental challenge in the post-genome era is to understand and annotate the
consequences of genetic variation, particularly within the context of human tissues. We …
consequences of genetic variation, particularly within the context of human tissues. We …
meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans
Identifying genetic variants that are associated with variation in DNA methylation, an
analysis commonly referred to as methylation quantitative trait locus (meQTL) mapping, is an …
analysis commonly referred to as methylation quantitative trait locus (meQTL) mapping, is an …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
[HTML][HTML] DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits
M Oliva, K Demanelis, Y Lu, M Chernoff, F Jasmine… - Nature …, 2023 - nature.com
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …
specific characterization of DNAm is needed to understand its role in gene regulation and its …
[PDF][PDF] Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci
Most genetic variants identified in genome-wide association studies (GWASs) of complex
traits are thought to act by affecting gene regulation rather than directly altering the protein …
traits are thought to act by affecting gene regulation rather than directly altering the protein …
Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels
DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels …
have revealed widespread associations between genetic variation and methylation levels …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Identification of 55,000 replicated DNA methylation QTL
DNA methylation plays an important role in the regulation of transcription. Genetic control of
DNA methylation is a potential candidate for explaining the many identified SNP …
DNA methylation is a potential candidate for explaining the many identified SNP …