Meta-analysis: anticholinergics, but not β-agonists, reduce severe exacerbations and respiratory mortality in COPD

SR Salpeter, NS Buckley, EE Salpeter - Journal of general internal …, 2006 - Springer
BACKGROUND: Anticholinergics and β2-agonists have generally been considered
equivalent choices for bronchodilation in chronic obstructive pulmonary disease (COPD) …

Bronchodilators in COPD: impact of β-agonists and anticholinergics on severe exacerbations and mortality

SR Salpeter - … Journal of Chronic Obstructive Pulmonary Disease, 2007 - Taylor & Francis
This review summarizes the long-term clinical outcomes associated with β-agonist and
anticholinergic bronchodilator use in patients with chronic obstructive pulmonary disease …

Systematic review of clinical outcomes in chronic obstructive pulmonary disease: β-Agonist use compared with anticholinergics and inhaled corticosteroids

SR Salpeter, NS Buckley - Clinical reviews in allergy & immunology, 2006 - Springer
Much controversy surrounds the use of β-agonists in obstructive lung disease. Regular β 2-
agonist use in asthma results in tolerance to its effects and an increase in asthma-related …

Anticholinergic bronchodilators versus beta2‐sympathomimetic agents for acute exacerbations of chronic obstructive pulmonary disease

DC McCrory, CD Brown… - Cochrane Database …, 1996 - cochranelibrary.com
Background Inhaled bronchodilators form the mainstay of treatment for acute exacerbations
of COPD. Two types of agent are used routinely, either singly or in combination …

Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta …

S Singh, YK Loke, CD Furberg - Jama, 2008 - jamanetwork.com
Context Inhaled anticholinergics (ipratropium bromide or tiotropium bromide) are widely
used in patients with chronic obstructive pulmonary disease (COPD) but their effect on the …

Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis

MA Puhan, LM Bachmann, J Kleijnen, G Ter Riet… - BMC medicine, 2009 - Springer
Background Most patients with chronic obstructive pulmonary disease (COPD) receive
inhaled long-acting bronchodilators and inhaled corticosteroids. Conventional meta …

Prevention of COPD exacerbations: a European respiratory Society/American thoracic Society guideline

JA Wedzicha, PMA Calverley, RK Albert… - European …, 2017 - Eur Respiratory Soc
This document provides clinical recommendations for the prevention of chronic obstructive
pulmonary disease (COPD) exacerbations. It represents a collaborative effort between the …

Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapies

RA Wise, DP Tashkin - The American journal of medicine, 2007 - Elsevier
Bronchodilators are the mainstay of chronic obstructive pulmonary disease (COPD) therapy.
Inhaled short-acting β2-agonists generally have a more rapid onset of effect and shorter …

Cardiovascular mortality and morbidity in chronic obstructive pulmonary disease: the impact of bronchodilator treatment

R Wood‐Baker, B Cochrane… - Internal Medicine …, 2010 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a substantial health burden.
Cardiovascular disease (CVD), the leading cause of death, frequently coexists with COPD …

Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed‐treatment comparison meta‐analysis

WL Baker, EL Baker, CI Coleman - … : The Journal of Human …, 2009 - Wiley Online Library
Study Objective. To assess the comparative efficacy of pharmacologic agents for the
maintenance treatment of chronic obstructive pulmonary disease (COPD). Design …