Gestational exposure to the AhR agonist 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin induces BRCA‐1 promoter hypermethylation and reduces BRCA‐1 expression in …
AJ Papoutsis, OI Selmin, JL Borg… - Molecular …, 2015 - Wiley Online Library
Studies with murine models suggest that maternal exposure to aromatic hydrocarbon
receptor (AhR) agonists may impair mammary gland differentiation and increase the …
receptor (AhR) agonists may impair mammary gland differentiation and increase the …
Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA‐induced mammary tumors
T Wang, HM Gavin, VM Arlt… - … Journal of Cancer, 2011 - Wiley Online Library
Abstract 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐dioxin (TCDD), the prototypic ligand for the aryl
hydrocarbon receptor (AhR), promotes tumor formation in some model systems. However …
hydrocarbon receptor (AhR), promotes tumor formation in some model systems. However …
[HTML][HTML] Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells
AJ Papoutsis, SD Lamore, GT Wondrak, OI Selmin… - The Journal of …, 2010 - Elsevier
The BRCA-1 protein is a tumor suppressor involved in repair of DNA damage. Epigenetic
mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet …
mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet …
A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
BA Vorderstrasse, SE Fenton, AA Bohn… - Toxicological …, 2004 - academic.oup.com
Many ligands for the aryl hydrocarbon receptor (AhR) are considered endocrine disruptors
and carcinogens, and assessment of adverse health effects in humans exposed to such …
and carcinogens, and assessment of adverse health effects in humans exposed to such …
[HTML][HTML] Genistein prevents BRCA1 CpG methylation and proliferation in human breast cancer cells with activated aromatic hydrocarbon receptor
DF Romagnolo, MG Donovan, AJ Papoutsis… - Current developments in …, 2017 - Elsevier
Background Previous studies have suggested a causative role for agonists of the aromatic
hydrocarbon receptor (AhR) in the etiology of breast cancer 1, early-onset (BRCA-1) …
hydrocarbon receptor (AhR) in the etiology of breast cancer 1, early-onset (BRCA-1) …
Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and …
D Sahay, SE Lloyd, JA Rivera, J Jezioro… - Environmental …, 2021 - Elsevier
Background Airborne polycyclic aromatic hydrocarbons (PAH) possess carcinogenic and
endocrine disrupting properties linked to mammary tumorigenesis. These effects may be …
endocrine disrupting properties linked to mammary tumorigenesis. These effects may be …
BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 cells
AJ Papoutsis, JL Borg, OI Selmin… - The Journal of nutritional …, 2012 - Elsevier
Epigenetic mechanisms may contribute to reduced expression of the tumor suppressor gene
BRCA-1 in sporadic breast cancers. Through environmental exposure and diet, humans are …
BRCA-1 in sporadic breast cancers. Through environmental exposure and diet, humans are …
Toxic and chemopreventive ligands preferentially activate distinct aryl hydrocarbon receptor pathways: implications for cancer prevention
ST Okino, D Pookot, S Basak, R Dahiya - Cancer Prevention Research, 2009 - AACR
The aryl hydrocarbon receptor (AhR) is a ligand-activated regulatory protein that controls
estrogen action through two distinct pathways. In one pathway, AhR acts as a transcription …
estrogen action through two distinct pathways. In one pathway, AhR acts as a transcription …
Benzo (a) pyrene, but not 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma …
L Zhang, KT Shiverick - Biochemical and biophysical research …, 1997 - Elsevier
This study compared the effects of benzo (a) pyrene (BaP) and 2, 3, 7, 8-tetrachlorodibenzo-
p-dioxin (TCDD), two aryl hydrocarbon receptor (AhR) agonists, on proliferation and gene …
p-dioxin (TCDD), two aryl hydrocarbon receptor (AhR) agonists, on proliferation and gene …
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells
The aryl hydrocarbon receptor (AhR) 3 is a ligand-activated transcription factor that forms a
functional heterodimeric complex with the AhR nuclear translocator (Arnt) protein. The …
functional heterodimeric complex with the AhR nuclear translocator (Arnt) protein. The …