In recent decades computer-aided technologies have become prevalent in medicine,
however, cancer drugs are often only tested on in vitro cell lines from biopsies. We derive a …

Intensive glioma tumor infiltration into the surrounding normal brain tissues is one of the
most critical causes of glioma treatment failure. To quantitatively understand and …

It has been shown recently that changing the fluidic properties of a drug can improve its
efficacy in ablating solid tumors. We develop a modeling framework for tumor ablation and …

We describe multiscale transport model, which was developed to simulate drug diffusion
and convection in tissues and drug vectors. Models rely on material properties and physical …

Certain brain tumours are very hard to treat with radiotherapy due to their irregular shape
caused by the infiltrative nature of the tumour cells. To enhance the estimation of the tumour …

Gliomas are primary brain tumours arising from the glial cells of the nervous system. The
diffuse nature of spread, coupled with proximity to critical brain structures, makes treatment a …

The treatment for many neurodegenerative diseases of the central nervous system (CNS)
involves the delivery of large molecular weight drugs to the brain. The blood brain barrier …

Effective drug delivery for many neurodegenerative diseases or tumors of the central
nervous system is challenging. Targeted invasive delivery of large macromolecules such as …

Most of the computational models of drug transport in vascular tumours assume a uniform
distribution of blood vessels through which anti-cancer drugs are delivered. However, it is …

Glioma is a common type of primary brain tumour, with a strongly invasive potential, often
exhibiting non-uniform, highly irregular growth. This makes it difficult to assess the degree of …