The PKD1 or PKD2 genes encode polycystins (PC) 1 and 2, which are associated with
polycystic kidney disease. Previously we demonstrated that PC2 interacts with the inositol 1 …

Autosomal dominant polycystic kidney disease, a common cause of renal failure, arises from
mutations in either the PKD1 or the PKD2 gene. The precise function of both PKD gene …

Autosomal dominant polycystic kidney disease is caused by loss-of-function mutations in the
PKD1 or PKD2 genes encoding respectively polycystin-1 and polycystin-2. Polycystin-2 …

Autosomal dominant polycystic kidney disease (ADPKD) types 1 and 2 arise as a
consequence of mutations in the PKD1 or PKD2 genes, encoding polycystins-1 and-2 …

The cytoplasmic C-terminal portion of the polycystin-1 polypeptide (PKD1 (1–226)) regulates
several important cell signaling pathways, and its deletion suffices to cause autosomal …

Abstract Background Polycystin-2 (PC2), encoded by the gene that is mutated in autosomal
dominant polycystic kidney disease (ADPKD), functions as a calcium (Ca 2+) permeable ion …

Mutations in polycystins-1 and-2 (PC1 and PC2) cause autosomal dominant polycystic
kidney disease (ADPKD), which is characterized by progressive development of epithelial …

Background Mutations of PKD2, which encodes polycystin-2, cause autosomal dominant
polycystic kidney disease (ADPKD). The prevailing view is that defects in polycystin-2 …

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder
largely caused by mutations in the PKD1 and PKD2 genes that encode the transmembrane …

Autosomal dominant polycystic kidney disease (ADPKD) arises following mutations of either
Pkd1 or Pkd2. The proteins these genes encode, polycystin-1 (PC1) and polycystin-2 (PC2) …