Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …

Neuroepigenetics considers genetic sequences and the interplay with environmental
influences to elucidate vulnerability risk for various neurological and psychiatric disorders …

Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …

Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry
concerns the extent to which epigenetic signatures measured in more accessible tissues …

Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …

Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …

Epigenetic mechanisms, including DNA methylation, that underlie neuropsychiatric
conditions have become a promising area of research. Most commonly used DNA sources …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

Objectives Aberrant DNA methylation and gene expression have been reported in
postmortem brain tissues of psychotic patients, but until now there has been no systematic …

Recent studies suggest that genetic and environmental factors do not account for all the
schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA …