Pharmacokinetic pharmacodynamic models are used in adult and paediatric anaesthesia.
The pharmacokinetic parameter volume is used to calculate loading dose while …

Background Sevoflurane pharmacokinetics have been traditionally described using
physiological models, while pharmacodynamics employed the use of minimal alveolar …

The use of pharmacokinetic-pharmacodynamic models has improved anaesthesia practice
in children through a better understanding of dose-concentration-response relationships …

Pharmacokinetic‐pharmacodynamic modeling and simulation can facilitate understanding
and prediction of exposure‐response relationships in children with acute or chronic pain …

Modelling and simulation continue to have an important role optimizing drug use during
anaesthesia. Models incorporating influential covariates that better describe drug …

Modeling the pharmacokinetics and pharmacodynamics of anesthetics in children is
performed as a response to the clinical need for safe and efficacious administration of drugs …

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical
methodology to provide a better understanding of the relationship between concentration …

Adult parameter estimates for pharmacokinetic models over-predict plasma concentrations
in children. Parameter sets that describe 3-compartment pharmacokinetic models for …

Adult parameter estimates for pharmacokinetic models over-predict plasma concentrations
in children. Parameter sets that describe 3-compartment pharmacokinetic models for …

In the paediatric population, developmental changes can be predicted by age and are
independent of size, which is predicted by body weight. Size is commonly standardised …