The constant decline in fertility and older reproductive age is the major cause of low clinical
pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

A societal preference of delaying maternal age at first childbirth has increased reliance on
assisted reproductive technologies/therapies (ART) to conceive a child. Oocytes that have …

Abstract BACKGROUND The Fifth Evian Annual Reproduction (EVAR) Workshop Meeting
discussed knowledge regarding contemporary genetics in female reproduction. METHODS …

BACKGROUND The Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed
knowledge regarding contemporary genetics in female reproduction. METHODS Specialist …

The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …

Our work reveals unknown aspects in oocyte aging. It mainly offers two substantial and
innovative advances: first, it investigates chromatin aging processes in the early stages of …

Recent advancements in genomic analysis allow testing of an increasing number of genetic
features in human preimplantation embryos. Typical single gene mutation and whole …

Epigenetic modifications acquired during oocyte growth are essential for transcriptional
regulation, establishment of maternal DNA methylation imprints, and the maintenance of …

Worldwide increase in life expectancy has boosted research on aging. Overcoming the
concept of chronological age, higher attention has been addressed to biological age, which …