Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and
diabetes. Although these risk factors are relatively constant throughout the arterial …

Haemodynamic factors influence all forms of vascular growth (vasculogenesis,
angiogenesis, arteriogenesis). Because of its prominent role in atherosclerosis, shear stress …

The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Atherosclerosis is a focal disease that develops preferentially where nonlaminar, disturbed
blood flow occurs, such as branches, bifurcations, and curvatures of large arteries …

Atherosclerosis is a chronic inflammatory disease that originates at regions of arteries
exposed to disturbances in fluid flow and results in progressive plaque formation in those …

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …