Two complex protein defense systems—complement and coagulation—are based on
amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The convergence between complement and the clotting system extends far beyond the
chemical nature of the complement and coagulation components, both of which form …

Complement and coagulation are evolutionarily related proteolytic cascades in the blood
that are critical for effecting an appropriate innate response to injury that limits bleeding and …

The coagulation and complement systems are ancestrally related enzymatic cascades of the
blood. Although their primary purposes have diverged over the past few hundred million …

The complement system is a key player in innate immunity and a major effector arm of
humoral immunity. Its activating components are a group of plasma proteins, whose …

Thromboembolic events represent the most common complication of hemolytic anemias
characterized by complement-mediated hemolysis such as paroxysmal nocturnal …

Objective The objective of this study was to describe complement activation in hemostatic
and pathologic states of coagulation and in the acquired and congenital hemolytic anemias …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

The complement system is a major component of the innate immune system and it provides
a powerful and effective mechanism to protect the host from pathogens. It was first described …