Background Recently, it has been proposed that epigenetic variation may contribute to the
risk of complex genetic diseases like cancer. We aimed to demonstrate that epigenetic …

Motivation: The standard paradigm in omic disciplines has been to identify biologically
relevant biomarkers using statistics that reflect differences in mean levels of a molecular …

Recently it has been observed that cancer tissue is characterised by an increased variability
in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA …

The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …

Epigenome‐wide association studies (EWAS) are designed to characterise population‐level
epigenetic differences across the genome and link them to disease. Most commonly, they …

Normal tissue at risk of neoplastic transformation is characterized by somatic mutations,
copy-number variation and DNA methylation changes. It is unclear however, which type of …

Background DNA methylation changes that accrue in the stem cell pool of an adult tissue in
line with the cumulative number of cell divisions may contribute to the observed variation in …

Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …

Excitement about DNA methylation biomarkers has been tempered by a growing
appreciation of the complex causal relations with cell fate. Intersample differences in DNA …

Differences in methylation across tissues are critical to cell differentiation and are key to
understanding the role of epigenetics in complex diseases. In this investigation, we found …