Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine)
has a profound impact on chromatin structure, gene expression and maintenance of cellular …

DNA methylation is one of the best-characterized epigenetic modifications,,,. Although the
enzymes that catalyse DNA methylation have been characterized, enzymes responsible for …

Methylation at the 5′ position of cytosine in DNA has important roles in genome function
and is dynamically reprogrammed during early embryonic and germ cell development. The …

Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in
regulating gene expression and maintaining cellular identity. Recently, TET1 was found to …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Inner cell mass (ICM) cells of a blastocyst, the source of embryonic stem (ES) cells, are
characterized by their unique ability to give rise to all cell types in adult organisms. The …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-
methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription,,,. However, the …

The epigenomes of early mammalian embryos are extensively reprogrammed to acquire a
totipotent developmental potential. A major initial event in this reprogramming is the active …

Meiosis is a germ-cell-specific cell division process through which haploid gametes are
produced for sexual reproduction. Before the initiation of meiosis, mouse primordial germ …