Long Noncoding RNA GAS5: A New Factor Involved in Bone Diseases

Z Zhou, J Chen, Y Huang, D Liu, S Chen… - Frontiers in Cell and …, 2022 - frontiersin.org
Long noncoding RNAs (lncRNAs), as an important type of RNA encoded in the human
transcriptome, have shown to regulate different genomic processes in human cells, altering …

Long noncoding RNA GAS5 suppresses cell growth and epithelial–mesenchymal transition in osteosarcoma by regulating the miR‐221/ARHI pathway

K Ye, S Wang, H Zhang, H Han, B Ma… - Journal of cellular …, 2017 - Wiley Online Library
Dysregulated long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in
the development of human cancers. The lncRNA growth arrest‐specific 5 (GAS5) is reported …

LncRNA GAS5 suppresses the proliferation and invasion of osteosarcoma cells via the miR-23a-3p/PTEN/PI3K/AKT pathway

J Liu, M Chen, L Ma, X Dang, G Du - Cell Transplantation, 2020 - journals.sagepub.com
Accumulating evidence has shown that long noncoding RNA GAS5 is a well-known tumor
suppressor in the pathogenesis of a variety of human cancers. However, the detailed role of …

Novel tumor suppressor lncRNA growth arrest-specific 5 (GAS5) in human cancer

Y Yu, SS Hann - OncoTargets and therapy, 2019 - Taylor & Francis
Long noncoding RNAs (lncRNAs) play crucial regulatory roles in fundamental biological
processes, and deregulations of lncRNAs have been linked to numerous human diseases …

lncRNA GAS5 regulates angiogenesis by targeting miR‑10a‑3p/VEGFA in osteoporosis

W Wu, Q Li, YF Liu, Y Li - Molecular Medicine Reports, 2021 - spandidos-publications.com
Osteoporosis is a severe bone disease commonly occurring in older males and
postmenopausal females. Previous studies have shown that long non‑coding (lnc) RNA …

The role of long non-coding RNA GAS5 in cancers

J Ji, X Dai, SCJ Yeung, X He - Cancer management and research, 2019 - Taylor & Francis
Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis
and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing …

GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

M Li, Z Xie, J Li, J Lin, G Zheng, W Liu, S Tang, S Cen… - Elife, 2020 - elifesciences.org
Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and
increased fracture risk. It is still necessary to explore its detailed mechanisms and identify …

The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers

C Ma, X Shi, Q Zhu, Q Li, Y Liu, Y Yao, Y Song - Tumor Biology, 2016 - Springer
Long noncoding RNAs (lncRNAs), which refer to a group of RNAs with length more than 200
nucleotides and limited protein-coding potential, play a widespread role in regulating …

Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 …

X Liu, Y She, H Wu, D Zhong, J Zhang - Journal of biomedical science, 2018 - Springer
Abstract Background LncRNA Gas5 is known to be a key control element during growth,
differentiation and development in mammalian species. However, the role and function of …

[HTML][HTML] The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells

X Zhang, K Du, Z Lou, K Ding, F Zhang… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Abstract Growth Arrest Specific 5 (GAS5), a long noncoding RNA (lncRNA), functions as a
tumor suppressor in multiple cancers. However, its function, downstream targets and …