Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Mammalian DNA methyltransferases: new discoveries and open questions
As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
Dnmt1: Structure and function
ŽM Svedružić - Progress in molecular biology and translational …, 2011 - Elsevier
Dnmt1, the principal DNA methyltransferase in mammalian cells, is a large and a highly
dynamic enzyme with multiple regulatory features that can control DNA methylation in cells …
dynamic enzyme with multiple regulatory features that can control DNA methylation in cells …
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
S Adam, H Anteneh, M Hornisch, V Wagner… - Nature …, 2020 - nature.com
DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …
An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function
DNA methylation is one of the principal epigenetic signals that participate in cell specific
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …
Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …