[HTML][HTML] YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
H Du, Y Zhao, J He, Y Zhang, H Xi, M Liu, J Ma… - Nature …, 2016 - nature.com
Methylation at the N 6 position of adenosine (m6A) is the most abundant RNA modification
within protein-coding and long noncoding RNAs in eukaryotes and is a reversible process …
within protein-coding and long noncoding RNAs in eukaryotes and is a reversible process …
[HTML][HTML] YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Abstract N 6-methyladenosine (m 6 A) is the most abundant internal modification in
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
[HTML][HTML] A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA
S Zaccara, SR Jaffrey - Cell, 2020 - cell.com
Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA nucleotide modification
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …
N6-methyladenosine-dependent regulation of messenger RNA stability
Abstract N 6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …
[HTML][HTML] Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition
Recent discoveries suggest that N6-methyladenosine (m6A) modification, a prevalent
internal modification in eukaryotic RNA, is an essential RNA regulatory mechanism. This …
internal modification in eukaryotic RNA, is an essential RNA regulatory mechanism. This …
YTHDF2 Recognition of N1-Methyladenosine (m1A)-Modified RNA Is Associated with Transcript Destabilization
KW Seo, RE Kleiner - ACS chemical biology, 2019 - ACS Publications
Epitranscriptomic modifications play an important role in RNA function and can impact gene
expression. Here, we apply a chemical proteomics approach to investigate readers of N1 …
expression. Here, we apply a chemical proteomics approach to investigate readers of N1 …
[HTML][HTML] m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Dynamic mRNA modification in the form of N 6-methyladenosine (m6A) adds considerable
richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed …
richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed …
[HTML][HTML] N6-methyladenosine modulates messenger RNA translation efficiency
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in
mammalian mRNA. This modification is reversible and non-stoichiometric and adds another …
mammalian mRNA. This modification is reversible and non-stoichiometric and adds another …
[HTML][HTML] m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Summary N 6-Methyladenosine (m 6 A), the most abundant internal mRNA modification,
affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m 6 A …
affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m 6 A …
[HTML][HTML] Molecular mechanisms driving mRNA degradation by m6A modification
N 6-Methyladenosine (m 6 A), the most prevalent internal modification associated with
eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export …
eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export …