Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

11β-hydroxysteroid dehydrogenases (11β-HSDs) catalyse the interconversion of active
cortisol and inert cortisone. Two isozymes have been discovered, each with unique …

Abstract 11β-hydroxysteroid dehydrogenases (11β-HSDs) catalyze the interconversion of
active glucocorticoids (cortisol, corticosterone) and inert 11-keto forms (cortisone, 11 …

Corticosteroids (glucocorticoids and mineralocorticoids) have multiple actions in the brain
which are mediated via specific intracellular receptors. Recently, a novel and important …

Increases in plasma cortisol and glucocorticoid pharmacotherapy cause myriad adverse
effects from obesity and diabetes to impairments in memory. The common metabolic …

Abstract 11β-Hydroxysteroid dehydrogenases (11β HSDs) are enzymes that catalyse the
interconversion of active glucocorticoids (cortisol and corticosterone) into their inactive 11 …

Glucocorticoids have a plethora of effects within the body to maintain homeostasis. In the
brain they modify learning, memory and fear behaviours as well as regulating their own …

Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes,
including hepatic gluconeogenesis. It recently has been recognized that intracellular …

11β-Hydroxysteroid dehydrogenase type 1 (11HSD1) catalyses the in vivo conversion of
inactive to active glucocorticoids. It is a widespread, highly regulated enzyme which …

Abstract 11β-Hydroxysteroid dehydrogenases (11β-HSDs) catalyze interconversion of active
corticosterone and inert 11-dehydrocorticosterone, thus regulating glucocorticoid access to …