Many psychiatric disorders are characterized by a strong sex difference, but the mechanisms
behind sex-bias are not fully understood. DNA methylation plays important roles in …

There is an increasing body of knowledge on the influence of differential DNA methylation of
specific genomic regions in psychiatric disorders. However, fewer studies have addressed …

There are well‐established sex differences in the prevalence of certain mental disorders.
Work in animal models has provided us with an emerging understanding of the role that …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

DNA methylation, which is modulated by both genetic factors and environmental exposures,
may offer a unique opportunity to discover novel biomarkers of disease-related brain …

Depressive disorders have been shown to be highly influenced by environmental
pathogenic factors, some of which are believed to exert stress on human brain functioning …

Brain function and cognitive performance differ between men and women in some
measures. The phenotypic variation may be partially due to sex differences in epigenomes …

Objective Major depressive disorder (MDD) arises from a combination of genetic and
environmental risk factors and DNA methylation is one of the molecular mechanisms …

DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …