Simple Summary Genes can be inactivated by specific modifications of DNA bases, most
often by adding a methyl group to the DNA base cytosine if it is followed by guanosine (CG …

Background The E-cadherin gene (CDH1) maps, at chromosome 16q22. 1, a region often
associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is …

Aberrant methylation of the promoter region has emerged as the major mechanism for
silencing tumor suppressor genes. However, for some genes, such as E-cadherin (CDH1) …

The E-cadherin gene (CDH1) is associated with poor prognosis and metastasis in patients
with breast cancer, and methylation of its promoter is correlated with decreased gene …

Breast cancer is the most common cancer in women around the world, and novel prognosis
strategies is needed to control more accurate and effective of this malignant disease. Among …

Promoter hypermethylation is known to result in transcriptional downregulation of many
genes including the CDH1 gene. In this study we set out to determine CDH1 promoter …

Gene promoter methylation causes loss of tumor suppressor genes function in human
cancer. Here, we show that the CDH4 gene, a member of the cadherin family encoding for R …

Expression of some members of the cadherin family is reduced in several human tumors,
and CDH13 (H-cadherin), located on chromosome 16q24. 2–3, may function as a tumor …

Background: Aberrant promoter hypermethylation has been recognized in human breast
carcinogenesis as a frequent molecular alteration associated with the loss of expression of a …

This study was designed to investigate the DNA-methylation status of E-cadherin (CDH1)
and H-cadherin (CDH13) in serum samples of cervical cancer patients and control patients …