Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Resistance to chemotherapy is a major obstacle in the treatment of cancer. Despite the
advent of new chemotherapies and molecular-targeted therapies, approximately 90% of …

Modulation of multidrug resistance (MDR) has been extensively studied in vitro and in vivo.
However, several clinical trials have failed to show any important benefits in terms of …

Drug resistance, to date, has primarily been attributed to increased drug export or
detoxification mechanisms. Despite correlations between drug export and drug resistance, it …

Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

Drug resistance remains a major clinical challenge for cancer treatment. One mechanism by
which tumor cells develop resistance to cytotoxic agents and radiation is related to …

Cancer drug resistance continues to be a major impediment in medical oncology. Clinically,
resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …

Over the past 10 years evidence has been accumulating that antitumour agents induce
apoptosis in cancer cells and that abnormalities in apoptosis signaling pathways often occur …

Although various mechanisms involved in anticancer multidrug resistance (MDR) can be
identified, it remains a major problem in oncology. Beyond that, the introduction of new …