Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Recent advances in our understanding of the genetic architecture of schizophrenia have
shed light on the schizophrenia etiology. While common variation is one of the major genetic …

Background Gene coexpression networks are relevant to functional and clinical translation
of schizophrenia risk genes. We hypothesized that schizophrenia risk genes converge into …

Background: Disruption in normal development of the human prefrontal cortex (PFC) may
lead to cognitive dysfunction that manifests in individuals with schizophrenia. We sought to …

Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …

Background Schizophrenia is a highly heritable brain disorder with a typical symptom onset
in early adulthood. The 2-hit hypothesis posits that schizophrenia results from differential …

The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …

Recent genome-wide association studies have identified many promising schizophrenia
candidate genes and demonstrated that common polygenic variation contributes to …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …