Hypoxia is involved in the epigenetic modification of leukemia. As an important DNA
hydroxymethylase and a tumor suppressor gene, the expression regulating mechanism of …

Hypoxia promotes tumor malignancy in solid tumors. One key mechanism by which this
occurs is via epigenetic alteration. The present study demonstrates that hypoxia upregulates …

Abstract Ten‐eleven translocation 1 (TET1), a widely reported DNA demethylation protein,
has been associated with tumorigenesis and metastasis. However, whether TET1 is an …

The epigenetic regulator dioxygenase Ten-eleven translocation 3 (TET3) catalyzes the
oxidation of 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) and plays an …

Expression and function of Ten-eleven translocation (TET) enzymes, which initiate DNA
demethylation by catalyzing the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5 …

DNA methylation plays significant roles in a variety of biological and pathological processes
including mammalian development, genomic imprinting, retrotransposon silencing, and X …

The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5mC) into 5-
hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive …

Abstract Background: 5-methylation (5-mC) is the predominant epigenetic mark in
mammalian genomic DNA. When promoter region of certain gene is hypermethylated, the …

DNA methylation is tightly regulated throughout mammalian development, and altered DNA
methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase …

Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a
wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5 …