Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm
R Roldán-Montero, JM Pérez-Sáez, I Cerro-Pardo… - Science …, 2022 - science.org
Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal
aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside …
aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside …
Gal-1 (Galectin-1) upregulation contributes to abdominal aortic aneurysm progression by enhancing vascular inflammation
MT Chiang, IM Chen, FF Hsu, YH Chen… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing
sudden rupture of aorta and significant mortality in elders. Nevertheless, no prognostic and …
sudden rupture of aorta and significant mortality in elders. Nevertheless, no prognostic and …
[HTML][HTML] Galectin-3 modulates macrophage activation and contributes smooth muscle cells apoptosis in abdominal aortic aneurysm pathogenesis
HY Lu, CM Shih, CY Huang, ATH Wu… - International journal of …, 2020 - mdpi.com
Galectin-3 (Gal-3) is a 26-kDa lectin that regulates many aspects of inflammatory cell
behavior. We assessed the hypothesis that increased levels of Gal-3 contribute to …
behavior. We assessed the hypothesis that increased levels of Gal-3 contribute to …
Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development
CE Fernandez-García, C Tarin… - Clinical …, 2017 - portlandpress.com
Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists
for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated …
for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated …
Galectin-3 identifies a subset of macrophages with a potential beneficial role in atherosclerosis
K Di Gregoli, M Somerville, R Bianco… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed
to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of …
to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of …
[HTML][HTML] Beneficial effects of galectin-3 blockade in vascular and aortic valve alterations in an experimental pressure overload model
Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification.
We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) …
We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) …
Galectin‐3 is a potential mediator for atherosclerosis
Z Gao, Z Liu, R Wang, Y Zheng, H Li… - Journal of immunology …, 2020 - Wiley Online Library
Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the
pathological basis of many cardiovascular diseases such as coronary heart disease, heart …
pathological basis of many cardiovascular diseases such as coronary heart disease, heart …
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction
M Papaspyridonos, E McNeill, JP de Bono… - … , and vascular biology, 2008 - Am Heart Assoc
Objective—Galectin-3 (Gal-3) is a 26-kDa lectin known to regulate many aspects of
inflammatory cell behavior. We assessed the hypothesis that increased levels of Gal-3 …
inflammatory cell behavior. We assessed the hypothesis that increased levels of Gal-3 …
[HTML][HTML] Unraveling the role of galectin-3 in cardiac pathology and physiology
IM Seropian, P Cassaglia, V Miksztowicz… - Frontiers in …, 2023 - frontiersin.org
Galectin-3 (Gal-3) is a carbohydrate-binding protein with multiple functions. Gal-3 regulates
cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions …
cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions …
Galectin-3 mediates aldosterone-induced vascular fibrosis
Objective—Aldosterone (Aldo) is involved in arterial stiffness and heart failure, but the
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …