Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Gene duplication and divergence via both the loss and gain of gene activities are powerful
evolutionary forces underlying the origin of new biological functions. Here a comparative …

Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival,
and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse …

As pathogenic microorganisms establish an infection, they must be able to sense host-
specific signals and respond by elaborating determinants that allow for survival in these …

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-
monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size …

Our earlier findings established that cyclic AMP-dependent protein kinase functions in a
signaling cascade that regulates mating and virulence of Cryptococcus neoformans var …

The basidiomycete fungus Cryptococcus neoformans is an important pathogen of
immunocompromised people. The ability of the fungus to sense its environment is critical for …

The polysaccharide capsule is one of the established virulence factors in Cryptococcus
neoformans that provides a barrier against the host-mediated immune response. Mutation of …

Cyclic AMP‐dependent protein kinase A (PKA) regulates elaboration of the virulence factors
melanin and polysaccharide capsule in Cryptococcus neoformans. A mutation in PKA1 …

More than 1.5 million fungal species are estimated to live in vastly different environmental
niches. Despite each unique host environment, fungal cells sense certain fundamentally …